Natures Aid Vitamin E 1000iu, Natural Source, High Strength, 30 Softgel Capsules

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Naturally occurring vitamin E exists in eight chemical forms (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) that have varying levels of biological activity [ 1]. Alpha- (or α-) tocopherol is the only form that is recognized to meet human requirements. Devore EE, Kang JH, Stampfer MJ, Grodstein F. The association of antioxidants and cognition in the Nurses’ Health Study. American journal of epidemiology. 2013 Jan 1;177(1):33-41. Christen WG, Glynn RJ, Chew EY, Buring JE. Vitamin E and age-related macular degeneration in a randomized trial of women. Ophthalmology. 2010;117:1163-8. Additionally, it seems that few or no liquid vitamin E supplements have undergone third-party testing. Dosage Research has not found any adverse effects from consuming vitamin E in food [ 6]. However, high doses of alpha-tocopherol supplements can cause hemorrhage and interrupt blood coagulation in animals, and in vitro data suggest that high doses inhibit platelet aggregation. Two clinical trials have found an increased risk of hemorrhagic stroke in participants taking alpha-tocopherol; one trial included Finnish male smokers who consumed 50 mg/day for an average of 6 years [ 53] and the other trial involved a large group of male physicians in the United States who consumed 400 IU (180 mg) of synthetic vitamin E every other day for 8 years [ 26]. Because the majority of physicians in the latter study were also taking aspirin, this finding could indicate that vitamin E has a tendency to cause bleeding.

Although some liquid vitamin E oils are available and can be taken orally, most are formulated to be applied directly to your skin. Alpha-tocopherol in dietary supplements and fortified foods is often esterified to prolong its shelf life while protecting its antioxidant properties. The body hydrolyzes and absorbs these esters (alpha-tocopheryl acetate and succinate) as efficiently as alpha-tocopherol [ 6]. Vitamin E Intakes and StatusLee JE, Giovannucci E, Smith-Warner SA, Spiegelman D, Willett WC, Curhan GC. Intakes of fruits, vegetables, vitamins A, C, and E, and carotenoids and risk of renal cell cancer. Cancer Epidemiol Biomarkers Prev. 2006;15:2445-52. Suplemen vitamin E bermanfaat untuk mencegah dan mengatasi kekurangan vitamin E. Suplemen ini diperlukan saat kebutuhan vitamin E secara alami dari makanan tidak tercukupi. Kekurangan vitamin E bisa terjadi pada penderita kondisi tertentu, seperti abetalipoproteinemia atau cystic fibrosis. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med. 1993;328:1444-9. Wang L, Sesso HD, Glynn RJ, Christen WG, Bubes V, Manson JE, Buring JE, Gaziano JM. Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians’ Health Study II randomized trial. The American journal of clinical nutrition. 2014 Sep 1;100(3):915-23.

Vitamin E supplements come in different amounts and forms. Two main things to consider when choosing a vitamin E supplement are: For example, a 2018 study in 54 people with diabetic nephropathy — kidney damage caused by high blood sugar — found that supplementing with 800 IU of vitamin E per day for 12 weeks significantly increased levels of glutathione peroxidase (GPx) compared with a placebo ( 4). Amyotrophic Lateral Sclerosis (ALS): One large prospective study that followed nearly 1 million people for up to 16 years found that people who regularly took vitamin E supplements had a lower risk of dying from ALS than people who never took vitamin E supplements. [47] More recently, a combined analysis of multiple studies with more than 1 million participants found that the longer people used vitamin E supplements, the lower their risk of ALS. [48] Clinical trials of vitamin E supplements in people who already have ALS have generally failed to show any benefit, however. [49] This may be a situation where vitamin E is beneficial for prevention, rather than treatment, but more research is needed.Klein EA, Thompson IM, Jr., Tangen CM, et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011;306:1549-56. Verhagen H, Buijsse B, Jansen E, Bueno-de-Mesquita B. The state of antioxidant affairs. Nutr Today 2006;41:244-50.

Zandi PP, Anthony JC, Khachaturian AS, et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol. 2004;61:82-8. Konsultasikan dengan dokter jika Anda berencana mengonsumsi vitamin E bersama obat, suplemen, atau produk herbal tertentu. Tujuannya adalah untuk mengantisipasi interaksi obat. Vitamin E supplements can help prevent deficiency, which may be particularly important for those who have chronic conditions that affect the digestion and absorption of fat ( 3, 4). Lippman SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009;301:39-51. Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL. Antioxidant vitamin supplements and cardiovascular disease. Circulation. 2004;110:637-41.In general, clinical trials have not provided evidence that routine use of vitamin E supplements prevents cardiovascular disease or reduces its morbidity and mortality. However, participants in these studies have been largely middle-aged or elderly individuals with demonstrated heart disease or risk factors for heart disease. Some researchers have suggested that understanding the potential utility of vitamin E in preventing CHD might require longer studies in younger participants taking higher doses of the supplement [ 27]. Further research is needed to determine whether supplemental vitamin E has any protective value for younger, healthier people at no obvious risk of CHD. Cancer Parkinson’s Disease: Some, but not all, prospective studies suggest that getting higher intakes of vitamin E from diet—not from high-dose supplements—is associated with a reduced risk of Parkinson’s disease. [43–45] In people who already have Parkinson’s, high-dose vitamin E supplements do not slow the disease’s progression. [46] Why the difference between vitamin E from foods versus that from supplements? It is possible that foods rich in vitamin E, such as nuts or legumes, contain other nutrients that protect against Parkinson’s disease. More research is needed.

Grodstein F, Chen J, Willett WC. High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. Am J Clin Nutr. 2003;77:975-84. The amount of vitamin E you need each day depends on your age. Average daily recommended amounts are listed below in milligrams (mg). Life Stage Vitamin E is an important vitamin that helps to protect cells from oxidative stress. The cells in our bodies start to age in an accelerated manner when exposed to molecules known as free radicals. These free radicals form naturally in the body and can interact with cells causing oxidative stress. Oxidative stress is a condition that occurs when there’s an imbalance between your body’s antioxidant defenses and the production and accumulation of compounds called reactive oxygen species (ROS). This can lead to cellular damage and increased disease risk ( 3). Those who prefer naturally sourced vitamin E may want to opt for supplements made with d-alpha tocopherol. Products that contain dl-alpha tocopherol are derived from synthetic vitamin E but are often more affordable. Is it OK to take vitamin E every day?Orrell RW, Lane RJ, Ross M. Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane Database Syst Rev. 2007:CD002829. Vitamin E consumption from foods or supplements was associated with less cognitive decline over 3 years in a prospective cohort study of elderly, free-living individuals age 65–102 years [ 48]. However, a clinical trial in primarily healthy older women who were randomly assigned to receive 600 IU (402 mg) d-alpha-tocopherol every other day or a placebo for ≤4 years found that the supplements provided no apparent cognitive benefits [ 49]. Another trial in which 769 men and women with mild cognitive impairment were randomly assigned to receive 2,000 IU/day vitamin E (form not specified), a cholinesterase inhibitor (donepezil), or placebo found no significant differences in the progression rate of Alzheimer's disease between the vitamin E and placebo groups [ 50] Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM, et al.; HOPE and HOPE-TOO Trial Investigators. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005;293:1338-47. [ PubMed abstract] There is no evidence of toxic effects from vitamin E found naturally in foods. Most adults who obtain more than the RDA of 22 IU daily are using multivitamins or separate vitamin E supplements that contain anywhere from 400-1000 IU daily. There have not been reports of harmful side effects of supplement use in healthy people. However, there is a risk of excess bleeding, particularly with doses greater than 1000 mg daily or if an individual is also using a blood thinning medication such as warfarin. For this reason, an upper limit for vitamin E has been set for adults 19 years and older of 1000 mg daily (1465 IU) of any form of tocopherol supplement. [1] Did You Know? Suplemen vitamin E dapat terserap ke dalam ASI, tetapi masih aman bila dikonsumsi sesuai dengan nilai angka kecukupan gizi harian. Konsultasikan dengan dokter perihal penggunaan vitamin E jika Anda sedang hamil atau menyusui.